If you downloaded and installed AutoCAD 2018 yesterday and don’t/won’t/can’t have Autodesk desktop app running on your systems, you may already have another download to do, because AutoCAD 2018.0.1 is out.
At the time of writing there is no sign of this update on Autodesk’s main site, but you can get at it using Autodesk Account. Go to Management > AutoCAD > Downloads > Updates & Add-ons.
All that’s downloaded is an executable. No readme, nothing. There is currently no official information about the reasons behind this update, what it includes, what it might affect, how to include it in a deployment, etc. You’ll need to make up your own mind whether to install this update now or wait for information about it. I suggest the latter.
What’s the worst that could happen?
Edit: see this post for further information.